Speaking of the sequel to Mass Effect today, BioWare Senior Manager Matt Atwood had the following to say about the upcoming title:

‘How will it correlate to Mass Effect, the original? There’s a lot of really exciting answers to that question. I think that people are going to be blown away.’

He also stated:
‘I’ve learned some of the things. I don’t mean to tease people. The
teams are just so brilliant and the story writing is so good that
straight out from the beginning of Mass Effect 2, people are going to
be in awe…I will tell you that things you did and people you
interacted with in Mass Effect… you may very well meet up with them
again, whether it be the main character or other characters.’